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Weight Loss / Metabolic

Semaglutide

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GLP-1 receptor agonist. Active ingredient in Ozempic and Wegovy. ~15% average weight reduction.

  • ~15% average body weight reduction (STEP trials)
  • Significant appetite suppression
  • Cardiovascular risk reduction (SELECT trial)
  • Blood sugar and HbA1c control
  • Weekly injection — convenient dosing
Start 0.25mg/week SubQ x4 weeks → 0.5mg → 1mg → 1.7mg → 2.4mg max (weight loss protocol).
~7 days
  • Contraindicated in personal/family history of MEN2 or medullary thyroid carcinoma
  • Pancreatitis risk — monitor for severe abdominal pain
  • Do not use in pregnancy
  • Diabetic retinopathy complications reported
  • Risk of hypoglycemia when combined with other glucose-lowering agents
Acute pancreatitis, gallbladder disease, acute kidney injury (secondary to dehydration), suicidal ideation (rare, under investigation).

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⚕️ This information is for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare provider before beginning any wellness protocol.
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